Publications + Abstracts

TR&D 1: Molecular Imaging Reagents for Prostate Cancer Theranostics


Zhihang Chen, Balaji Krishnamachary, Marie-France Penet, Sangeeta Ray, Martin Pomper, Zaver M. Bhujwalla. PSMA-targeted biodegradable dextran to delivery PD-L1 siRNA in prostate cancer. 2017 WMIC, Sept. 13-16, 2017, Philadelphia, USA.


Chen Z, Krishnamachary B, Penet MF, Bhujwalla ZM. Acid-degradable Dextran as an Image Guided siRNA Carrier for COX-2 Downregulation. Theranostics. 2018 Jan 1;8(1):1-12. doi: 10.7150/thno.21052. eCollection 2018.

TR&D 2: Optimizing and Humanizing a Reporter Gene for Imaging in Deep Tissue


J.W.M. Bulte, H.E Daldrup-Link. Clinical tracking of cell transfer and cell transplantation: Trials and tribulations. Radiology 289, 604-615 (2018).

L. Alon, D.L. Kraitchman, M. Schär, A. Cortez, N.N. Yadav, J. Cook, P. Johnston, R. Krimins, M.T. McMahon, P.C.M. van Zijl, S. Nimmagadda, M.G. Pomper, J.W.M. Bulte, A.A. Gilad.  Molecular imaging of CXCL12 promoter-driven HSV1-TK reporter gene expression. Biotech. Bioproc. Eng., 23, 208-217 (2018).

A. Bar-Shir, L. Alon, M. Korrer, H.S. Lim, N.N. Yadav, Y. Kato, A.P. Pathak, J.W.M. Bulte, A.A. Gilad. Quantification and tracking of genetically engineered dendritic cells for studying immunotherapy. Magn. Reson. Med. 79, 1010-1019 (2018).

Meier S, Gilad AA, Brandon JA, Qian C, Gao E, Abisambra JE, Vandsburger M. Non-invasive detection of adeno-associated viral gene tgransfer using a genetically encoded CEST-MRI reporter gene in the murine heart. Sci Rep. 2018 Mar 15;8(1):4638. doi: 10.1038/s41598-018-22993-4.

TR&D 3: Imaging Agents for Inflammatory Components of Malignancy


R. Naik, V. Misheneva, I. Minn, T. Melnikova, W. Mathews, R.F. Dannals, M.G. Pomper, A. Savonenko, M. Pletnikov, A.G. Horti. PET tracer for imaging of macrophage colony stimulating factor receptor (CSF1R). Society of Nuclear Medicine and Molecular Imaging, Philadelphia, PA 2018.

Dhiraj Kumar, Ala Lisok, Samit Chatterjee, Bryan Wharram, Ronnie Mease, Martin Pomper and Sridhar Nimmagadda. A highly specific hydrophilic peptide for PET imaging of PD-L1 expression in tumors. Society of Nuclear Medicine and Molecular Imaging, Philadelphia, PA 2018.

Katherine Zukotynski, Steven P. Rowe, John Valliant, Chun K. Kim, Martin G. Pomper and Steve Y. Cho. 18F-DCFPyL PET/CT in Castration-Resistant Prostate Cancer (CRPC): Imaging results prior to and following abiraterone or enzalutemide therapy. Society of Nuclear Medicine and Molecular Imaging, Philadelphia, PA 2018.


Horti AG, Naik R, Foss CA, Minn I, Misheneva V, Du Y, Wang Y, Mathews WB, Wu Y, Hall A, LaCourse C, Ahn HH, Nam H, Lesniak WG, Valentine H, Pletnikova O, Troncoso JC, Smith MD, Calabresi PA, Savonenko A, Dannals RF, Pletnikov MV, Pomper MG. PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R). Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1686-169, PMID: 30635412. PMCID: PMC6358677

TR&D 4: CEST MRI Agents for Receptor Imaging


S. Ray Banerjee, X. Song, X. Yang, I. Minn, A. Lisok, Y. Chen, A. Bui, S. Chatterjee, J. Chen, P.C.M. van Zijl, M.T. McMahon, M. G. Pomper, “Salicylic Acid-Based Polymeric Contrast Agents for Targeted Molecular Magnetic Resonance Imaging of Prostate Cancer”, J Nucl Med May 1, 2017 vol. 58 no. supplement 1 732

Heo HY, Jiang S, van Zijl PCM, Zhou J. A Novel MR Fingerprinting (MRF) Approach for fast quantitative Chemical Exchange Saturation Transfer MRI analysis by Subgrouping Proton Exchange Models (CESTSPEM). Intl. Soc. Mag. Reson. Med. 2018. Power Pitch.


Liu G, Ray Banerjee S, Yang X, Yadav N, Lisok A, Jablonska A, Xu J, Li Y, Pomper MG, van Zijl P. A dextran-based probe for the targeted magnetic resonance imaging of tumours expressing prostate-specific membrane antigen. Nat Biomed Eng. 2017;1:977-982. doi: 10.1038/s41551-017-0168-8. Epub 2017 Dec 12. PMID: 29456877; PMCID: PMC5810963.

Han Z, Zhang S, Fujiwara K, Zhang J, Li Y, Liu J, van Zijl PCM, Lu ZR, Zheng L, Liu G. An extradomain-B fibronectin-targeted dextran-based CEST MRI probe for detecting pancreatic cancer. Bioconjug Chem. 2019 Apr 2. doi:10.1021/acs.bioconjchem.9b00161. [Epub ahead of print] PubMed PMID: 30938983.

Xu X, Xu J, Knutsson L, Liu J, Liu H, Li Y, Lal B, Laterra J, Artemov D, Liu G, van Zijl PCM, Chan KWY. The effect of the mTOR inhibitor rapamycin on glucoCEST signal in a preclinical model of glioblastoma. Magn Reson Med. 2019 Jun;81(6):3798-3807. doi: 10.1002/mrm.27683. Epub 2019 Feb 22. PubMed PMID: 30793789.

Zhou J, Heo HY, Knutsson L, van Zijl PCM, Jiang S. APT-weighted MRI: Techniques, current neuro applications, and challenging issues. J Magn Reason Imaging. 2019 Jan 20. doi: 10.1002/jmri.26645. [Epub ahead of print] Review. PubMed PMID: 30663162.

Heo HY, Han Z, Jiang S, Schär M, van Zijl PCM, Zhou J. Quantifying amide proton exchange rate and concentration in chemical exchange saturation transfer imaging of the human brain. Neuroimage. 2019 Apr 1;189:202-213. doi: 10.1016/j.neuroimage.2019.01.034. Epub 2019 Jan 14. PubMed PMID: 30654175; PubMed Central PMCID: PMC6422734.

Knutsson L, Seidemo A, Rydhög Scherman A, Markenroth Bloch K, Kalyani RR, Andersen M, Sundgren PC, Wirestam R, Helms G, van Zijl PCM, Xu X. Arterial Input Functions and Tissue Response Curves in Dynamic Glucose-Enhanced (DGE) Imaging: Comparison Between glucoCEST and Blood Glucose Sampling in Humans. Tomography. 2018 Dec;4(4):164-171. doi: 10.18383/j.tom.2018.00025. PubMed PMID: 30588502; PubMed Central PMCID: PMC6299743.

Chen L, Wei Z, Chan KWY, Cai S, Liu G, Lu H, Wong PC, van Zijl PCM, Li T, Xu J. Protein aggregation linked to Alzheimer's disease revealed by saturation transfer MRI. Neuroimage. 2019 Mar;188:380-390. doi: 10.1016/j.neuroimage.2018.12.018. Epub 2018 Dec 13. PubMed PMID: 30553917; PubMed Central PMCID: PMC6401270.

Chen L, Barker PB, Weiss RG, van Zijl PCM, Xu J. Creatine and phosphocreatine mapping of mouse skeletal muscle by a polynomial and Lorentzian line-shape fitting CEST method. Magn Reson Med. 2019 Jan;81(1):69-78. doi: 10.1002/mrm.27514. Epub 2018 Sep 23. PubMed PMID: 30246265; PubMed Central PMCID: PMC6258268.

Sehgal AA, Li Y, Lal B, Yadav NN, Xu X, Xu J, Laterra J, van Zijl PCM. CEST MRI of 3-O-methyl-D-glucose uptake and accumulation in brain tumors. Magn Reason Med. 2019 Mar;81(3):1993-2000. doi: 10.1002/mrm.27489. Epub 2018 Sep 11. PubMed PMID: 30206994; PubMed Central PMCID: PMC6347504.

Xu X, Xu J, Chan KWY, Liu J, Liu H, Li Y, Chen L, Liu G, van Zijl PCM. GlucoCEST imaging with on-resonance variable delay multiple pulse (onVDMP) MRI. Magn Reson Med. 2019 Jan;81(1):47-56. doi: 10.1002/mrm.27364. Epub 2018 Jul 29. PubMed PMID: 30058240; PubMed Central PMCID: PMC6258333.

Liu J, Han Z, Chen G, Li Y, Zhang J, Xu J, van Zijl PCM, Zhang S, Liu G. CEST MRI of sepsis-induced acute kidney injury. NMR Biomed. 2018 Aug;31(8):e3942. doi: 10.1002/nbm.3942. Epub 2018 Jun 13. PubMed PMID: 29897643.

Knutsson L, Xu J, Ahlgren A, van Zijl PCM. CEST, ASL, and magnetization transfer contrast: How similar pulse sequences detect different phenomena. Magn Reson Med. 2018 Oct;80(4):1320-1340. doi: 10.1002/mrm.27341. Epub 2018 May 30. Review. PubMed PMID: 29845640; PubMed Central PMCID: PMC6097930.

Liu J, Bai R, Li Y, Staedtke V, Zhang S, van Zijl PCM, Liu G. MRI detection of bacterial brain abscesses and monitoring of antibiotic treatment using bacCEST. Magn Reson Med. 2018 Aug;80(2):662-671. doi: 10.1002/mrm.27180. Epub 2018 Mar 25. PubMed PMID: 29577382; PubMed Central PMCID: PMC5910221.

Banerjee SR, Song X, Yang X, Minn I, Lisok A, Chen Y, Bui A, Chatterjee S, Chen J, van Zijl PCM, McMahon MT, Pomper MG. Salicylic Acid-Based Polymeric Contrast Agents for Molecular Magnetic Resonance Imaging of Prostate Cancer. Chemistry. 2018 May 17;24(28):7235-7242. doi: 10.1002/chem.201800882. Epub 2018 Apr 26. PubMed PMID: 29508450; PubMed Central PMCID: PMC5980787.

Chen L, Xu X, Zeng H, Chan KWY, Yadav N, Cai S, Schunke KJ, Faraday N, van Zijl PCM, Xu J. Separating fast and slow exchange transfer and magnetization transfer using off-resonance variable-delay multiple-pulse (VDMP) MRI. Magn Reason Med. 2018 Oct;80(4):1568-1576. doi: 10.1002/mrm.27111. Epub 2018  Feb 5. PubMed PMID: 29405374; PubMed Central PMCID: PMC6077103.