Material Requests
PC3 PIP
PSMA-positive prostate cancer cell line.
Shipping & Processing Fee: $300 per line
References:
A PSMA-Targeted Theranostic Agent for Photodynamic Therapy.
Chen Y, et al. J Photochem Photobiol B 2018.
PMID 28063300
Low-Level Endogenous PSMA Expression in Nonprostatic Tumor Xenografts Is Sufficient for In Vivo Tumor Targeting and Imaging.
Nimmagadda S, et al. J Nucl Med 2018.
PMID 29025989
PC3 flu
PSMA-negative prostate cancer cell line.
Shipping & Processing Fee: $300 per line
References:
A PSMA-Targeted Theranostic Agent for Photodynamic Therapy.
Chen Y, et al. J Photochem Photobiol B 2018.
PMID 28063300
Low-Level Endogenous PSMA Expression in Nonprostatic Tumor Xenografts Is Sufficient for In Vivo Tumor Targeting and Imaging.
Nimmagadda S, et al. J Nucl Med 2018.
PMID 29025989
CHO-hPD-L1
CHO cell line stably expressing human PD-L1.
Shipping & Processing Fee: $300 per line
References:
PD-L1 Detection in Tumors Using [(64)Cu]Atezolizumab with PET.
Lesniak WG, et al. Bioconjug Chem 2016. Among authors: Nimmagadda S. PMID 27458027 Free PMC article.
Rapid PD-L1 detection in tumors with PET using a highly specific peptide.
Chatterjee S, et al. Biochem Biophys Res Commun 2017. Among authors: Nimmagadda S. PMID 28025143 Free PMC article.
Peptide-Based (68)Ga-PET Radiotracer for Imaging PD-L1 Expression in Cancer.
De Silva RA, et al. Mol Pharm 2018. Among authors: Nimmagadda S. PMID 30037229 Free PMC article.
Peptide-based PET quantifies target engagement of PD-L1 therapeutics.
Kumar D, et al. J Clin Invest 2019. Among authors: Nimmagadda S. PMID 30457978 Free PMC article.
A humanized antibody for imaging immune checkpoint ligand PD-L1 expression in tumors.
Chatterjee S, et al. Oncotarget 2016. Among authors: Nimmagadda S. PMID 26848870 Free PMC article.
Olsa-RVRR
Olsalazine (Olsa, green) is an aspirin/salicylic acid) analogue that acts as a cancer theranostic: it is a broad spectrum anti-cancer agent (DNA methylation inhibitor) that can be detected with CEST MRI at 9.8 ppm. The conjugated RVRR is a substrate for the tumor-overexpressed enzyme furin. The compound Olsa-RVRR is available with or without conjugation to a CBT group (pink) for intracellular self-assembly of Olsa-RVRR nanoparticles in tumor cells. Compounds with specificities for other tumor enzymes (i.e., legumain) will be available soon.
Shipping & Processing Fee: To Be Determined
References:
Furin-mediated intracellular self-assembly of olsalazine nanoparticles for enhanced magnetic resonance imaging and tumour therapy.
Yuan Y et al. Nat Mater. 2019. Among authors: Bulte JWM. PMID: 31636420
Furin-Mediated Self-Assembly of Olsalazine Nanoparticles for Targeted Raman Imaging of Tumors.
Yuan Y et al. Angew Chem Int Ed Engl. 2021. Among authors: Bulte JWM. PMID: 33325142
SPIO-labeled MSC-EVs
SPIO-labeled MSC-EVs for use as immunomodulatory bimodal MRI contrast agents and MPI tracers.
Shipping & Processing Fee: To Be Determined
References:
Highly efficient magnetic labeling allows MRI tracking of the homing of stem cell-derived extracellular vesicles following systemic delivery.
Han Z et al. J Extracell. Vesicles. 2021.
Unlabeled, mannose-rich MSC-EVs
Unlabeled, mannose-rich MSC-EVs for use as immunomodulatory MRI diaCEST contrast agents.
Shipping & Processing Fee: To Be Determined
References:
In vivo tracking of unlabeled mesenchymal stromal cells by mannose-weighted chemical exchange saturation transfer MRI.
Yuan Y et al. Nat Biomed. 2022.
The Resource for Molecular Imaging Agents in Precision Medicine offers a variety of resources and materials available for researchers to utilize. Information about available materials and how to request them can be found below.