Material Requests

PC3 PIP

PSMA-positive prostate cancer cell line.

 

Shipping & Processing Fee: $300 per line

References: 

A PSMA-Targeted Theranostic Agent for Photodynamic Therapy.

Chen Y, et al. J Photochem Photobiol B 2018.

PMID 28063300

Low-Level Endogenous PSMA Expression in Nonprostatic Tumor Xenografts Is Sufficient for In Vivo Tumor Targeting and Imaging.

Nimmagadda S, et al. J Nucl Med 2018.

PMID 29025989

PC3 flu

PSMA-negative prostate cancer cell line.

Shipping & Processing Fee: $300 per line

References: 

A PSMA-Targeted Theranostic Agent for Photodynamic Therapy.

Chen Y, et al. J Photochem Photobiol B 2018.

PMID 28063300

Low-Level Endogenous PSMA Expression in Nonprostatic Tumor Xenografts Is Sufficient for In Vivo Tumor Targeting and Imaging.

Nimmagadda S, et al. J Nucl Med 2018.

PMID 29025989

CHO-hPD-L1

CHO cell line stably expressing human PD-L1. 

Shipping & Processing Fee: $300 per line

References: 

PD-L1 Detection in Tumors Using [(64)Cu]Atezolizumab with PET.
Lesniak WG, et al. Bioconjug Chem 2016. Among authors: Nimmagadda S. PMID 27458027 Free PMC article.


Rapid PD-L1 detection in tumors with PET using a highly specific peptide.
Chatterjee S, et al. Biochem Biophys Res Commun 2017. Among authors: Nimmagadda S. PMID 28025143 Free PMC article.

 

Peptide-Based (68)Ga-PET Radiotracer for Imaging PD-L1 Expression in Cancer.
De Silva RA, et al. Mol Pharm 2018. Among authors: Nimmagadda S. PMID 30037229 Free PMC article.

 

Peptide-based PET quantifies target engagement of PD-L1 therapeutics.
Kumar D, et al. J Clin Invest 2019. Among authors: Nimmagadda S. PMID 30457978 Free PMC article.

 

A humanized antibody for imaging immune checkpoint ligand PD-L1 expression in tumors.

Chatterjee S, et al. Oncotarget 2016. Among authors: Nimmagadda S. PMID 26848870 Free PMC article.

Olsa-RVRR

Olsalazine (Olsa, green) is an aspirin/salicylic acid) analogue that acts as a cancer theranostic: it is a broad spectrum anti-cancer agent (DNA methylation inhibitor) that can be detected with CEST MRI at 9.8 ppm. The conjugated RVRR is a substrate for the tumor-overexpressed enzyme furin. The compound Olsa-RVRR is available with or without conjugation to a CBT group (pink) for intracellular self-assembly of Olsa-RVRR nanoparticles in tumor cells. Compounds with specificities for other tumor enzymes (i.e., legumain) will be available soon.

Shipping & Processing Fee: To Be Determined

References:

Furin-mediated intracellular self-assembly of olsalazine nanoparticles for enhanced magnetic resonance imaging and tumour therapy.

Yuan Y et al. Nat Mater. 2019. Among authors: Bulte JWM. PMID: 31636420

Furin-Mediated Self-Assembly of Olsalazine Nanoparticles for Targeted Raman Imaging of Tumors.

Yuan Y et al. Angew Chem Int Ed Engl. 2021. Among authors: Bulte JWM. PMID: 33325142

SPIO-labeled MSC-EVs

SPIO-labeled MSC-EVs for use as immunomodulatory bimodal MRI contrast agents and MPI tracers.

Shipping & Processing Fee: To Be Determined

References:

Highly efficient magnetic labeling allows MRI tracking of the homing of stem cell-derived extracellular vesicles following systemic delivery.

Han Z et al. J Extracell. Vesicles. 2021.

Gd-DOTA-PEG-DSPE-labeled MSC-EVs

Gd-DOTA-PEG-DSPE-labeled MSC-EVs for use as immunomodulatory positive MRI contrast agent.

Shipping & Processing Fee: To Be Determined

Gd-DTPA-PE-labeled MSC-EVs

Gd-DPTA-PE-labeled MSC-EVs for use as immunomodulatory positive MRI contrast agents.

Shipping & Processing Fee: To Be Determined

Unlabeled, mannose-rich MSC-EVs

Unlabeled, mannose-rich MSC-EVs for use as immunomodulatory MRI diaCEST contrast agents.

Shipping & Processing Fee: To Be Determined

References:

In vivo tracking of unlabeled mesenchymal stromal cells by mannose-weighted chemical exchange saturation transfer MRI.

Yuan Y et al. Nat Biomed. 2022.

CPPC PET Precursor

Shipping & Processing Fee: To Be Determined

References:

First-in-human use of 11C-CPPC with positron emission tomography for imaging that macrophage colony stimulating factor 1 receptor.

Coughlin JM et al. EJNMMI. in press.

XYIMSR PET Precursor

Shipping & Processing Fee: To Be Determined

References:

A dual-motif CAIX ligand for PET imaging of clear cell renal cell carcinoma.

Minn I et al. Oncotarget. 2016

FNDP PET Precursor

Shipping & Processing Fee: To Be Determined

References:

First-in-human neuroimaging of soluble epoxide hydrolase using [18F]FNDP PET.

Coughlin JM et al. Eur J Nucl Med Mol Imaging. 2021.

CSF1R PET Precursor

Shipping & Processing Fee: To Be Determined

References:

PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R).

Horti AG et al. Proc Natl Acad Sci USA. 2019

The Resource for Molecular Imaging Agents in Precision Medicine offers a variety of resources and materials available for researchers to utilize. Information about available materials and how to request them can be found below.